Effect of Milling Parameters and Cr Content on Morphology and
The mixtures were milled in a high energy ball mill (pulverisette 4 Vario-Plantary Mill, Fritsch) with a ball to powder weight ratio of 10:1 and ethanol as process control agent. The steel vial of the ball mill had 250 ml capacity. 21.858 g of powders were put into the container and equal number of steel balls of 1 and 2 cm in diameters were added.
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Overview of milling techniques for improving the solubility
The use of ball milling as a micronization technique for enhancing drug solubility is well supported by literature dating as far back as the 1970s. Apart from its comminution function, ball milling also serves as an intensive mixing technique capable of producing co-ground drug-excipient mixtures comprising amorphous drug forms intimately mixed
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The Analysis of the Physicochemical Properties of Benzocaine
The study was a pioneering attempt to assess the influence of the structural polymorphism (forms I, II, III) of benzocaine on its solubility, apparent solubility, and chemical stability, which are vital parameters for preformulation and formulation work.
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Defining the process parameters affecting the fabrication of
These factors include i) milling time-related parameters (pause time, number of milling cycles and time of each cycle), ii) speed, iii) milling ball size, and iv) solid to solvent ratio. Nanosization by planetary ball mill significantly resulted in enhancing the dissolution rate and bioavailability of different drugs, like clarithromycin 5 and
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Improving product quality in pharmaceutical ball milling
Ball milling is used in the pharmaceutical industry to reduce the size of particulate material such as pharmaceutical granules. Dr Alexander Krok and Dr Sandra Lenihan from Munster Technological University, Ireland, have developed a computational approach to achieve optimal, energy-efficient size reduction in ball milling resulting in the production of high-quality particulate material (i.e
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High-Energy Ball Milling Parameters in Production of
The minimum achievable grain size and extent of alloying depend on a number of parameters i.e., type of high-energy ball mill, milling container, ball-to-powder weight ratio, milling speed, grinding medium, extent of filling of the vial, milling atmosphere, process controlling agents, milling temperature, type of material being milled etc. Synthesis of nanocrystalline metals and alloys, using
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Effect of Cr to Fe on the Solid Solubility, Lattice Parameter
-Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic technique were carried out at
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Solubility Study in Ag-Cu Binary System Prepared By Ball
Solubility Study in Ag-Cu Binary System Prepared By Ball Milling Process S. M. M. Shafiei*, E. Salahi, S. A. Tayebi Fard Materials and Energy Research Center (MERC) (*) Corresponding author: [email protected] (Received:18 Mar. 2012 and Accepted: 23 June 2012) Abstract: Solid solutions of Ag-Cu were prepared via ball milling process, for
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Optimization of ball milling parameters to produce Centella
Nanopowders of Centella asiatica was produced using planetary ball mill by varying milling parameters such as milling time, mass concentration, and bead amount. Particle size analysis employing photon correlation spectroscopy was carried out to record the effect of milling parameters on the particle size produced. The morphology of milled powders was also analyzed using a field emission
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Improving product quality in pharmaceutical ball milling
Ball milling is used in the pharmaceutical industry to reduce the size of particulate material such as pharmaceutical granules. Dr Alexander Krok and Dr Sandra Lenihan from Munster Technological University, Ireland, have developed a computational approach to achieve optimal, energy-efficient size reduction in ball milling resulting in the production of high-quality particulate material (i.e
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Defining the process parameters affecting the fabrication of
These factors include i) milling time-related parameters (pause time, number of milling cycles and time of each cycle), ii) speed, iii) milling ball size, and iv) solid to solvent ratio. Nanosization by planetary ball mill significantly resulted in enhancing the dissolution rate and bioavailability of different drugs, like clarithromycin 5 and
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Solubility and dissolution rate enhancement of ibuprofen by
In the first-part, two excipients (HPMC and soluplus) were selected from seven, and the optimal ball-milling parameters of speed and time (18 Hz, 15 min) were determined based on solubility-enhancement and flow-ability criteria.
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High Energy Ball Milling Mechanochemical Processing Of
High-energy ball milling is a ball milling process in which a powder mixture placed in a ball mill is subjected to high-energy collisions from the balls. High-energy ball milling, also called mechanical alloying, can successfully produce fine, uniform dispersions of oxide particles in nickel-base super alloys that
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Application of the combination of ball-milling and hot-melt
The effect of time and frequency of the ball milling process on the extrudates were determined. The ball milling frequency was set 20, 30, or 40 Hz and the milling time to 30 min. Then, the milling time was set to 30, 40, and 50 min at milling frequency of 30 Hz. The samples were fed into the extrusion system.
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Effect of ball milling on the physicochemical properties of
However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of unstable amorphous parts.
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Metals | Free Full-Text | Electrochemical Kinetic Analysis of
Electrochemical kinetic parameters for carbon steel powders produced by high-energy ball milling for 2, 3, and 5 h and immersed in NaOH and NaCl solutions are tabulated in Table 2. The results were obtained from the deconstruction of polarization curves in terms of the superposition model and the mixed-potential theory [ 44 , 45 ].
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Polymers | Free Full-Text | Solubility Improvement of
The mixtures were transferred into 10 mL zirconium oxide lined grinding jars containing one 12 mm diameter aluminium oxide ceramic milling ball and milled at a frequency of 30 s −1 for 5 min using a Retsch MM200 mill (Castleford, UK). The product was collected and sieved with an 80 μm orifice sieve.
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THE EFFECT OF BALL MILL OPERATING PARAMETERS ON MINERAL
by mill operating parameters. It is hoped that this work can be used as a precursor to the development of a model that can predict liberation given the various ranges of operating parameters. Mill speed, mill charge, ball size, and wet grinding are the parameters which have been selected for the present study. It is hoped that the analysis of the
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Effect of ball milling on the physicochemical properties of
However, the K a also increased with milling time increased, it showed a maximum at 2.7 × 10 −3 /s at 30-min milling, and then it decreased to 1.56 × 10 −3 /s by 60-min milling. The higher solubility than that of the intact crystal was due to the involvement of unstable amorphous parts.
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The Effect of Milling Time and Speed on Solid Solubility
The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ball-milling time was varied from 10 to 100 hours. The ball-milled alloys were consolidated under uniaxial pressure of 3GPa at room temperature. The solid solubility of V
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(PDF) Ball mill based on co-milling, a promising way to
Ball mill based on co-milling, a promising way to enhance solubility of poorly soluble drugs employing norfloxacin as model drug January 2018 Acta Poloniae Pharmaceutica 75(1):155-165
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(PDF) Ball mill based on co-milling, a promising way to
Ball mill based on co-milling, a promising way to enhance solubility of poorly soluble drugs employing norfloxacin as model drug January 2018 Acta Poloniae Pharmaceutica 75(1):155-165
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The Analysis of the Physicochemical Properties of Benzocaine
The study was a pioneering attempt to assess the influence of the structural polymorphism (forms I, II, III) of benzocaine on its solubility, apparent solubility, and chemical stability, which are vital parameters for preformulation and formulation work.
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The influence of milling conditions on the Ni ce alloyed powder
The effects of milling parameters such as balls diameters and ball milling speed defined by the number of balls from vials is an important parameter a milling process. extended solubility
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Solubility parameters for some reported carbon materials
Exfoliation rates in planetary ball mills can be improved when combining the milling with sonication [57] or when designed molecules are added, for example, 1-pyrene carboxylic acid [96] or
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The influence of milling conditions on the Ni ce alloyed powder
The effects of milling parameters such as balls diameters and ball milling speed defined by the number of balls from vials is an important parameter a milling process. extended solubility
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Improvement in solubility of poor water-soluble drugs by
The solubility of a drug is intrinsically related to the particle size. Reduction of particle size of a drug by various means such as jet mill, rotor stator colloidal mill, ball mill, etc. leads to increase in surface area with enhanced dissolution.
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Milling Parameters
The end mill speed is calculated with the following formula: n [rpm] = (vc [m/min] *1000) / 3.14 * ø d1 [mm]) Example calculation: vc = 500 m/min (selected from chart) d = ø 8 mm. 19904 rpm = ( 500 *1000) / (3.14 * 8) If the maximum speed of the milling motor is lower than the calculated value, the maximum speed of the milling motor needs to
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Effect of Ball-Milling Treatment on Physicochemical and
In this study, chitosan flake was micronized in a ball mill to make fine powder. The effects of the milling on properties of chitosan, such as particle size, molecular parameters, bulk density, crystalline structure, color, chemical structure, and solubility, were investigated.
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The influence of milling conditions on the Ni ce alloyed powder
The effects of milling parameters such as balls diameters and ball milling speed defined by the number of balls from vials is an important parameter a milling process. extended solubility
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